Selenium Dioxide → 2-(3,5-Difluorophenyl)-2-oxoacetaldehyde

Reaction equation

[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([F:11])[CH:5]=1)=[O:3].[Se](=O)=[O:13]>>[F:11][C:6]1[CH:5]=[C:4]([C:2](=[O:3])[CH:1]=[O:13])[CH:9]=[C:8]([F:10])[CH:7]=1

Participants

Reactant 2

HCID 24007Selenium Dioxide

HCID 5185963',5'-Difluoroacetophenone

Product 1

HCID 187847012-(3,5-Difluorophenyl)-2-oxoacetaldehydeYield 85.6%

Procedure

(3,5-Difluorophenyl)(oxo)acetaldehyde (28 g, 84%) was prepared from 3,5-difluoro acetophenone (30.0 g, 192.3 mmol) and selenium dioxide (23.55 g, 214.0 mmol) according to the typical procedure used for Preparation 1.

Workup

customused for Preparation 1

Sources & evidence

ORD record: ord-060a619f5ae64f888d1bb22a131848f1
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249130B2

Reaction notes

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