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HCID 71766904, compound → HCID 71766907, compound

HRID 1771409
Notes
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Reaction equation

HRID 1771409 reaction equation
Cl[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][O:6][CH:7]2[C:12]1[NH:13][CH2:14][CH2:15][N:16]=1.[C:17]([Zn]C#N)#[N:18]>CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C.CN(C=O)C>[NH:13]1[CH2:14][CH2:15][N:16]=[C:12]1[CH:7]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:2]([C:17]#[N:18])[C:3]=2[CH2:4][CH2:5][O:6]1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 71766904HCID 71766904, compoundHCID 178514179HCID 178514179, compound

Product 1

HCID 71766907HCID 71766907, compound

Reagents, catalysts & solvents 2

HCID 178418851HCID 178418851, compoundCatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
160 °C

Procedure

A mixture of 2-(5-chloroisochroman-1-yl)-4,5-dihydro-1H-imidazole (50 mg), dicyanozinc (25 mg), bis(tri-t-butylphosphine)palladium(0) (3 mg) and DMF (2 ml) was stirred in microwave reactor at 160° C. for 30 minutes. The title compound was purified with separation methods F and G. (Yield 22 mg).

Workup

  1. customThe title compound was purified with separation methods F and G

Sources & evidence

ORD record
ord-cc1510cec0f14b289b154a84fc77cdcd
Source dataset
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09249127B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes