Acetamide → HCID 71765898, compound
Reaction equation
[NH:1]1[CH2:5][CH2:4][N:3]=[C:2]1[CH:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]#[N:17])[C:10]=2[CH2:9][CH2:8][O:7]1.C(N)(=[O:20])C.C1COCC1>Cl[Zn]Cl.O>[NH:3]1[CH2:4][CH2:5][N:1]=[C:2]1[CH:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH2:17])=[O:20])[C:10]=2[CH2:9][CH2:8][O:7]1Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
The mixture of 1-(4,5-dihydro-1H-imidazol-2-yl)isochroman-5-carbonitrile (example 5, 75 mg), acetamide (39 mg), zink chloride (45 mg), THF (0.5 ml) and water (0.5 ml) was heated in a microwave reactor for 50 seconds at 320 W. The title compound was purified by applying method A. (Yield 15 mg).
Workup
- temperaturewas heated in a microwave reactor for 50 seconds at 320 W
- customThe title compound was purified
Sources & evidence
- ORD record
- ord-6038a7abf8234ff4bbe99a25a0c0e96e
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09249127B2
Reaction notes
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