Methyl iodide → 1,3-Dichloro-4-methoxy-2-nitrobenzene
Reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[CH:5]=[CH:4][C:3]=1[OH:12].[C:13]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Cl:11][C:6]1[CH:5]=[CH:4][C:3]([O:12][CH3:13])=[C:2]([Cl:1])[C:7]=1[N+:8]([O-:10])=[O:9]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2,4-dichloro-3-nitro-phenol (600 mg, 2.9 mmol, 1.0 eq) in acetone (30 mL), was added K2CO3 (1.2 g, 8.7 mmol, 3.0 eq) and the solution was stirred at room temperature for 30 min. Methyl iodide (1.2 g, 8.7 mmol, 3.0 eq) was added and the reaction was stirred at room temperature overnight. The reaction was filtered to remove the inorganic salts and the organic phase was evaporated in vacuo to give the title compound (550 mg, 86%).
Workup
- stirringthe reaction was stirred at room temperature overnight
- filtrationThe reaction was filtered
- customto remove the inorganic salts
- customthe organic phase was evaporated in vacuo
Sources & evidence
- ORD record
- ord-7074dac009fa46b0a988e9fe93fd5563
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09249085B2
Reaction notes
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