Water → HCID 178419284, compound
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[CH:10]=[N:9][NH:8][C:5]2=[CH:6][N:7]=1.C1C(=O)N([I:18])C(=O)C1.O>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([I:18])=[N:9][NH:8][C:5]2=[CH:6][N:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution containing 5-bromo-1H-pyrazolo[3,4-c]pyridine (168.0 g, 848.4 mmol) and NIS (286.3 g, 1.27 mol) in DMF (1.2 L) was stirred on at room temperature. The reaction mixture was poured into water then filtered. The solid was washed with water and 5% Na2S2O5. The crude product was dried under high vacuum overnight to give 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine.
Workup
- filtrationthen filtered
- washThe solid was washed with water and 5% Na2S2O5
- dry with materialThe crude product was dried under high vacuum overnight
Sources & evidence
- ORD record
- ord-849bcbca85004f7cad2bcf9fa1ac2de1
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09260425B2
Reaction notes
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