Hydrochloric Acid → 1-(4-Methylpyridin-2-YL)-1,4-diazepane dihydrochloride
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:3]=1.[ClH:22]>C(Cl)Cl>[ClH:22].[ClH:22].[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:3]=1Participants
4
Procedure
tert-Butyl 4-(4-methyl-2-pyridyl)-1,4-diazepane-1-carboxylate (91 mg, 0.312 mmol) was dissolved in DCM under nitrogen. Hydrochloric acid (4N in dioxane, 1.56 ml, 6.25 mmol) was added and the mixture was stirred at room temperature overnight. The mixture was evaporated under reduced pressure to give 84 mg of a solid (quantitative). MS (ESI) m/z=192.2 [M+1]+.
Workup
- customThe mixture was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-a280c5f7ab0341599c4603ad1af6eb67
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09260441B2
Reaction notes
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