Hydrochloric Acid → 2-Methyl-3-(piperidin-4-yl)pyridine hydrochloride
Reaction equation
[CH3:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:21]>CO>[ClH:21].[CH3:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
tert-Butyl 4-(2-methyl-3-pyridyl)piperidine-1-carboxylate (100 mg, 0.36 mmol) was dissolved in methanol (4 ml) and combined with hydrochloric acid (4N in dioxane, 10 ml) and the mixture was stirred at room temperature for two hours. The volatiles were removed under reduced pressure to yield 54 mg of a beige solid (0.25 mmol, 69%) MS (ESI) m/z=177.1 [M+1]+.
Workup
- customThe volatiles were removed under reduced pressure
Sources & evidence
- ORD record
- ord-ac158981a4d1402f8019e38bc8b14812
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09260441B2
Reaction notes
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