Sodium ethoxide → HCID 89826007, compound
Reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([N+]([O-])=O)[CH:5]=[C:4]([CH3:11])[N+:3]=1[O-:12].[O-:13][CH2:14][CH3:15].[Na+]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([O:13][CH2:14][CH3:15])[CH:5]=[C:4]([CH3:11])[N+:3]=1[O-:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Bromo-6-methyl-4-nitro-pyridine 1-oxide (1 g, 4.3 mmol) was dissolved in ethanol (anhydrous, 50 ml), and sodium ethoxide (21% in ethanol, 1.4 ml, 4.3 mmol) was added dropwise with stirring. The mixture was stirred at room temperature overnight, concentrated under reduced pressure, the residue was taken up in DCM (50 ml), the mixture was washed with water (50 ml), dried (sodium sulfate) and concentrated under reduced pressure to yield 0.84 g of brown yellow crystals (3.6 mmol, 84%).
Workup
- stirringThe mixture was stirred at room temperature overnight
- concentrationconcentrated under reduced pressure
- washthe mixture was washed with water (50 ml)
- dry with materialdried (sodium sulfate)
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-e5ae67b001544e7cbbf79b18a5c49923
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09260441B2
Reaction notes
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