Triethylamine → 3-Nitrooxy-propyl hexanoate
Reaction equation
[N+:1]([O:4][CH2:5][CH2:6][CH2:7][OH:8])([O-:3])=[O:2].C(N(CC)CC)C.[C:16](Cl)(=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>C(OCC)C>[C:16]([O:8][CH2:7][CH2:6][CH2:5][O:4][N+:1]([O-:3])=[O:2])(=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
20 mmol 3-Nitrooxypropanol dissolved in 10 ml Diethylether and 20 mmol Triethylamine were cooled to 0° C. 18.2 mmol hexoylchlorid were dropped over a period of 5 minutes at 0 to 5° C. After 19 hours stirring without cooling, the reaction mixture was extracted with 1N HCl, twice with water, washed with brine, dried over Na2SO4 and the solvent was removed in vacuo leaving 3.1 g.
Workup
- temperaturewithout cooling
- extractionthe reaction mixture was extracted with 1N HCl, twice with water
- washwashed with brine
- dry with materialdried over Na2SO4
- customthe solvent was removed in vacuo
- customleaving 3.1 g
Sources & evidence
- ORD record
- ord-c4a2063d7aa746b795570185b067c6fa
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09266814B2
Reaction notes
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