Hydrochloric Acid → HCID 67973995, compound

Reaction equation

[OH-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[C:7]([O:9]C)=[O:8].Cl>C(O)C>[F:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[C:7]([OH:9])=[O:8]

Participants

Procedure

A solution of sodium hydroxide 2M (1 mL; 2 mmol) was added to a solution of methyl 3-fluoro-4-(3-fluorobenzyl)benzoate (0.143 g; 0.545 mmol) in ethanol (1 mL). The mixture was stirred at room temperature for 1 hour and the pH of the solution was adjusted to 1 by addition of a solution of 6N hydrochloric acid. The precipitate was collected by filtration and dried under reduced pressure to give 0.111 g (82%) of 3-fluoro-4-(3-fluorobenzyl)benzoic acid as a white solid.