Potassium Carbonate → 3-(4-Bromophenyl)piperidin-2-one
Reaction equation
Cl.C(OC(=O)[CH2:6][CH:7]([C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1)[CH2:8][CH2:9][CH2:10][NH2:11])C.C(=O)([O-])[O-:21].[K+].[K+]>C(O)C>[Br:18][C:15]1[CH:16]=[CH:17][C:12]([CH:7]2[CH2:8][CH2:9][CH2:10][NH:11][C:6]2=[O:21])=[CH:13][CH:14]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 6-amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride, potassium carbonate (1039 mg, 7.52 mmol) in ethanol (50 ml) was refluxed for 20 hr. Solvent was removed in vacuo after addition of dilute hydrochloric acid and water was added to the residue. Filtration, wash with water and dryness afforded 3-(4-Bromo-phenyl)-piperidin-2-one (1387 mg, 86%, 2 steps).
Workup
- customSolvent was removed in vacuo
- additionafter addition of dilute hydrochloric acid and water
- additionwas added to the residue
- filtrationFiltration
- washwash with water and dryness
Sources & evidence
- ORD record
- ord-a1fbf437c99243d6ad6d224e40c0c375
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07504411B2
Reaction notes
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