Hydrazine hydrate (1:1) → HCID 67549266, compound
Reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH2:8][C:7]1=[O:12])C.O.[NH2:15][NH2:16]>C(O)CCC>[O:12]=[C:7]1[CH2:8][O:9][CH2:10][CH2:11][N:6]1[CH2:5][C:4]([NH:15][NH2:16])=[O:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
As described for example 112a, (3-oxo-morpholin-4-yl)-acetic acid ethyl ester in butanol was reacted with hydrazine hydrate at 100° C. for 6 h. Evaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1) afforded the title compound as a white solid (yield: 56%). MS: m/e=174.4 [M+H]+.
Workup
- customEvaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1)
Sources & evidence
- ORD record
- ord-f35efdd69a31478bb964ca8976c7d05e
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07507729B2
Reaction notes
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