Hydrazine hydrate (1:1) → HCID 386624, compound
Reaction equation
C(O[C:4](=[O:11])[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[N:7]1)C.O.[NH2:13][NH2:14]>C(O)C>[N:6]1([CH2:5][C:4]([NH:13][NH2:14])=[O:11])[CH:10]=[CH:9][N:8]=[N:7]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 4 °C
Procedure
As described for example 112a, [1,2,3]triazol-1-yl-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (2 equivalents) and the resulting mixture heated under reflux for 3 h. The mixture was cooled to 4° C. and the precipitated product was filtered off and dried to afford the title compound as a white solid (yield: 73%). MS: m/e=141.2[M]+.
Workup
- temperaturethe resulting mixture heated
- temperatureunder reflux for 3 h
- filtrationthe precipitated product was filtered off
- customdried
Sources & evidence
- ORD record
- ord-df034769d2a5441a92f005e51f5705b4
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07507729B2
Reaction notes
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