Lithium Hydroxide → 2-(4-Cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid
Reaction equation
C([O:4][C:5](=[O:24])[CH:6]([O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[C:14]([C:20]([F:23])([F:22])[F:21])[CH:13]=1)[CH2:7][CH:8]([CH3:10])[CH3:9])(C)C.[Li+].[OH-]>O>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([O:11][CH:6]([CH2:7][CH:8]([CH3:10])[CH3:9])[C:5]([OH:24])=[O:4])=[CH:13][C:14]=1[C:20]([F:21])([F:23])[F:22])#[N:19]Participants
4
Procedure
An admixture of 2-(4-cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid isopropyl ester (1A) (0.22 g, 0.67 mmol in 20 ml of dry tetrahydrofuran “THF”), LiOH (0.28 g, 6.7 mmol) and water (20 ml) is refluxed at 100° C. for 3 hours, then it is cooled to room temperature, the THF is removed, the crude product is diluted with 100 ml of ethyl acetate, and HCl(1N) to adjusted PH=1. The organic layer is separated and dried on vacuum to get the desired product.