Acetic Acid → tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate

Reaction equation

[CH3:24][CH2:25][OH:26].[CH3:30][C:31](=[O:32])[OH:33].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([C:11]3=[CH:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]3)[cH:6][nH:7][c:8]2[cH:9][cH:10]1.[Pt:27](=[O:28])=[O:29]>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([CH:11]3[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]3)[cH:6][nH:7][c:8]2[cH:9][cH:10]1

Participants

Reactant 4

HCID 176Acetic Acid

HCID 702Ethanol

HCID 345198Adams' catalyst

HCID 12072032tert-butyl 4-(5-chloro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 12072033tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate

Sources & evidence

ORD record: ord-ca61e8b384ef4fa0a9e856ac023b2031
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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