Ammonia → L-Aspartic Acid

HRID 1790861Notes

Reaction equation

HRID 1790861 reaction equation
[C:1]([O-:9])(=[O:8])[CH:2]([CH2:4][C:5]([O-:7])=[O:6])O.[Na+].[Na+].[NH3:12].C(O)(=O)C(CC(O)=O)O>>[NH2:12][C@H:2]([C:1]([OH:9])=[O:8])[CH2:4][C:5]([OH:7])=[O:6]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 525Malic AcidHCID 8736Malic acid, disodium salt

Product 1

HCID 5960L-Aspartic Acid

Procedure

The concentrations of the substrates prior to entering the reactor were 0.168 M for sodium malate and 1.797 M for aqueous ammonia. The reaction time was 0.181 second, and the aqueous solution obtained after the reaction was examined with a high performance liquid chromatography/mass spectroscopy apparatus, which confirmed that an amino group had been introduced into the malic acid, and that aspartic acid had been produced. The aspartic acid concentration was 4.2 mM, and the reaction yield thereof was 2.5%.

Workup

  1. customthe aqueous solution obtained after the reaction

Sources & evidence

ORD record
ord-22128d0e18414868bd6ebb4b112f1466
Source dataset
uspto-grants-2006_07
Patent number
US07071350B2

Reaction notes

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