Malic acid, disodium salt

HCID 8736CAS 22798-10-3

Basic information

Standard SMILES
O=C([O-])CC(O)C(=O)[O-].[Na+].[Na+]
InChIKey
WPUMTJGUQUYPIV-UHFFFAOYSA-L
Molecular formula
C4H4Na2O5
Average molar mass
178.05 g/mol
Monoisotopic mass
177.98541179

Overview

On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Malic Acid and Sodium Malate are safe for use as pH adjusters in cosmetic formulations. The Expert Panel determined that the data are insufficient to determine the safety of these ingredients for any other functions.

Names & identifiers

Preferred name
Malic acid, disodium salt
IUPAC
disodium;2-hydroxybutanedioate
English name
DL-Malic acid disodium salt
Molecular formula
C4H4Na2O5
Molecular weight
178.05

Names & synonyms

Malic acid, disodium saltRefChem:887666Sodium malate676-46-0Disodium malateDL-Malic acid disodium saltdisodium 2-hydroxybutanedioateDisodium DL-malate22798-10-3disodium;2-hydroxybutanedioateSODIUM DL-MALATESodium 2-hydroxysuccinate
Show more names
DISODIUM DL-MALATE HYDRATEMALIC ACID, SODIUMDI-SODIUM DL-MALATEDL-MALIC ACID SODIUMMalicaciddisodiumsaltdl-malic acid disodiumDl-MalicAcid,SodiumSaltSODIUM DL-MALATE HYDRATEDI-SODIUM MALATE 0.5-WATER
Sodium DL-maleateButanedioic acid, hydroxy-, disodium saltDTXSID7046831malic acid sodium saltMFCD00012466L-HYDROXYBUTANEDIOICACIDDISODIUMSALT2EFF9N315F63474-37-3

Database identifiers

CAS
22798-10-3、40520-93-2、676-46-0
PubChem CID
8736
DTXSID
DTXSID7046831
ChEMBL
CHEMBL182856
UNII
2EFF9N315F
EC Number
211-627-6、254-952-9、866-020-4
Nikkaji
J3.317K

Properties

Computed structural properties

Topological polar surface area
100 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
5
Rotatable bonds
1
Heavy atoms
11

Experimental & physicochemical properties

Cosmetics · 2 items

Cosmetic ingredients (Sodium Malate) -> CIR (Cosmetic Ingredient Review)

Humectant; Skin conditioning

SolubilityFreely soluble in water
Physical DescriptionWhite crystalline powder or lumps

Physicochemical properties

Melting point
300 °C · >300 °C(lit.)
CAS DataBase Reference
22798 · 22798-10-3(CAS DataBase Reference)
Symbol(GHS)
7 · GHS07
Signal word
Warning
Hazard statements
335 · H335-H315-H319
Precautionary statements
264 · P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 45.8% (65 of 142) of reports.

Warning

H315 (41.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 142 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

This chemical does not meet GHS hazard criteria for 100% (37 of 37) of all reports.

Hazard information

Regulatory Information · 2 items

Chemical: Butanedioic acid, hydroxy-, disodium salt

Disodium malate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Butanedioic acid, hydroxy-, disodium salt: Human health tier I assessment
Hazard Classes and Categories · 3 items

Skin Irrit. 2 (41.5%)

Skin Irrit. 2 (100%)

Not Classified

Toxicology

Toxicity Summary · 2 items

On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Malic Acid and Sodium Malate are safe for use as pH adjusters in cosmetic formulations. The Expert Panel determined that the data are insufficient to determine the safety of these ingredients for any other functions.

Safe for use in cosmetics, with qualifications

Safety data

wgk
3
rtecs
ON7730000
Signal word
Warning
Symbol(GHS)
GHS07
Hazard statements
H335-H315-H319
Precautionary statements
P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Chemistry & industry

Uses & manufacturing

UsesCIR ingredient: Sodium Malate
Use Classification · 4 items

Food additives

Flavouring Agent -> FLAVOURING_AGENTFood Additives -> ACIDITY_REGULATOR -> JECFA Functional Classes

Flavouring Agent -> FLAVOURING_AGENTFood Additives -> ACIDITY_REGULATOR -> JECFA Functional Classes

Cosmetics -> Humectant; Skin conditioning

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
上海康朗生物科技有限公司021-61998208 18217752821 · [email protected]
上海哲研生物科技有限公司021-18017610038 18017610038 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]

Related reactions

5 records

Linked notes

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