Basic information
- Standard SMILES
O=C([O-])CC(O)C(=O)[O-].[Na+].[Na+]- InChIKey
WPUMTJGUQUYPIV-UHFFFAOYSA-L- Molecular formula
- C4H4Na2O5
- Average molar mass
- 178.05 g/mol
- Monoisotopic mass
- 177.98541179
Overview
On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Malic Acid and Sodium Malate are safe for use as pH adjusters in cosmetic formulations. The Expert Panel determined that the data are insufficient to determine the safety of these ingredients for any other functions.
Names & identifiers
- Preferred name
- Malic acid, disodium salt
- IUPAC
- disodium;2-hydroxybutanedioate
- English name
- DL-Malic acid disodium salt
- Molecular formula
- C4H4Na2O5
- Molecular weight
- 178.05
Names & synonyms
Show more names
Database identifiers
- CAS
22798-10-3、40520-93-2、676-46-0- PubChem CID
- 8736
- DTXSID
DTXSID7046831- ChEMBL
CHEMBL182856- UNII
- 2EFF9N315F
- EC Number
- 211-627-6、254-952-9、866-020-4
- Nikkaji
- J3.317K
Properties
Computed structural properties
- Topological polar surface area
- 100 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 1
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 118
Experimental & physicochemical properties
Cosmetics
Cosmetic ingredients (Sodium Malate) -> CIR (Cosmetic Ingredient Review)
Humectant; Skin conditioning
Physicochemical properties
- Melting point
- 300 °C · >300 °C(lit.)
- CAS DataBase Reference
- 22798 · 22798-10-3(CAS DataBase Reference)
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 335 · H335-H315-H319
- Precautionary statements
- 264 · P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
- WGK Germany
- 3 · 3
- RTECS
- 7730000 · ON7730000
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 45.8% (65 of 142) of reports.
Warning
H315 (41.5%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 142 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
This chemical does not meet GHS hazard criteria for 100% (37 of 37) of all reports.
Hazard information
Regulatory Information
Chemical: Butanedioic acid, hydroxy-, disodium salt
Disodium malate: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories
Skin Irrit. 2 (41.5%)
Skin Irrit. 2 (100%)
Not Classified
Toxicology
Toxicity Summary
On the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that Malic Acid and Sodium Malate are safe for use as pH adjusters in cosmetic formulations. The Expert Panel determined that the data are insufficient to determine the safety of these ingredients for any other functions.
Safe for use in cosmetics, with qualifications
Safety data
- wgk
- 3
- rtecs
- ON7730000
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H335-H315-H319
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Chemistry & industry
Uses & manufacturing
Use Classification
Food additives
Flavouring Agent -> FLAVOURING_AGENTFood Additives -> ACIDITY_REGULATOR -> JECFA Functional Classes
Flavouring Agent -> FLAVOURING_AGENTFood Additives -> ACIDITY_REGULATOR -> JECFA Functional Classes
Cosmetics -> Humectant; Skin conditioning
Suppliers50 total
Related reactions
Linked notes
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