5-Ethenylpyridin-2-amine → 5-Ethylpyridin-2-amine
Reaction equation
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1)=[CH2:2]>C(OCC)(=O)C.[C].[Pd]>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1)[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
0.25 g 5-vinylpyridin-2-yl amine (compound in Production Example 326) and 0.1 g of 10% palladium-carbon were stirred in 5 mL ethyl acetate at room temperature for 2 hours under hydrogen atmosphere. The reaction solution was purified by NH silica gel column chromatography (ethyl acetate), to give 0.24 g of the title compound as a pale yellow oil.
Workup
- customThe reaction solution was purified by NH silica gel column chromatography (ethyl acetate)
Sources & evidence
- ORD record
- ord-09aab869bb414c14b748af51fb8fca97
- Source dataset
- uspto-grants-2006_07
- Patent number
- US07074801B1
Reaction notes
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