Trifluoroacetic acid → HCID 178434508, compound
Reaction equation
[CH3:1][N:2]([CH3:46])[C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][N:24](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)=[O:4].FC(F)(F)C(O)=O>>[CH3:1][N:2]([CH3:46])[C:3]([N:5]1[CH2:6][CH2:7][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][NH:24][CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:9][CH2:10]1)=[O:4]Participants
3
Procedure
38 mg N,N-dimethyl 4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide obtained in Example 182 and 0.2 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 16 mg of the title compound as pale yellow crystals.
Sources & evidence
- ORD record
- ord-5f2bbce63b7b434e86998dcb5ac0ff9f
- Source dataset
- uspto-grants-2006_07