Dichloromethane → 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-3-ylmethoxy)quinazoline

HRID 180149

Reaction equation

HRID 180149 reaction equation
[CH2:32]([P:33]([CH2:34][CH2:35][CH2:36][CH3:37])[CH2:38][CH2:39][CH2:40][CH3:41])[CH2:42][CH2:43][CH3:44].[CH2:45]([Cl:46])[Cl:47].[CH3:23][N:24]1[CH2:25][CH:26]([CH2:30][OH:31])[CH2:27][CH2:28][CH2:29]1.[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([OH:19])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1>>[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:30][CH:26]4[CH2:25][N:24]([CH3:23])[CH2:29][CH2:28][CH2:27]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 13831TributylphosphineHCID 97998(1-Methyl-3-piperidyl)methanolHCID 1355137204-(4-Chloro-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline

Product 1

HCID 224781994-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-3-ylmethoxy)quinazoline

Sources & evidence

ORD record
ord-1666f0aba24146b1a540b5b802a0f96c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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