Trifluoroacetic acid → Trifluoroacetic acid
Reaction equation
[CH3:1][C:2]1[S:6][C:5]([NH:7]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[CH3:1][C:2]1[S:6][C:5]([NH2:7])=[CH:4][CH:3]=1.[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16]Participants
5
Reactant 2
Product 2
Reagents, catalysts & solvents 1
Procedure
A solution of tert-butyl 5-methylthiophen-2-ylcarbamate (0.825 g, 3.87 mmol) in CH2Cl2 (10 mL) and TFA (6 mL) wad stirred at room temperature for 20 h. Solvents was removed in vacuo to give 5-methylthiophen-2-amine as trifluoroacetic acid salt (0.870 g).
Workup
- customSolvents was removed in vacuo
Sources & evidence
- ORD record
- ord-f8067d3468024887b2b7ee94b5b69920
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08349860B2
Reaction notes
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