tert-butyl 4-(1H-pyrazol-1-yl)piperidine-1-carboxylate → 4-(1H-Pyrazol-1-yl)piperidine

HRID 1804593

Reaction equation

HRID 1804593 reaction equation
[N:1]1([CH:6]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH:5]=[CH:4][CH:3]=[N:2]1>Cl.O1CCOCC1>[N:1]1([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH:5]=[CH:4][CH:3]=[N:2]1

Participants

4

Reactant 1

HCID 67971778tert-butyl 4-(1H-pyrazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 211930454-(1H-Pyrazol-1-yl)piperidineYield 96%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The title compound from Step B above (50 mg, 0.2 mmol) was dissolved in 4 M HCl in dioxane (2.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-17) (30 mg, 96%). ESI-MS calculated for C81H13N3: Exact Mass: 151.11. Found 152.10.

Workup

  1. concentrationThe product was concentrated under reduced pressure
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-82c09d36b50e44e199295577f8c352ee
Source dataset
uspto-grants-2013_01
Patent number
US08354403B2

Linked notes

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