Isopropanol → 2-Isopropoxypyrimidine

HRID 18048

Reaction equation

HRID 18048 reaction equation
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(NC(C)C)(C)C.[CH:15]([OH:18])([CH3:17])[CH3:16]>>[CH:15]([O:18][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1)([CH3:17])[CH3:16]

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 7912DiisopropylamineHCID 744042-Chloropyrimidine

Product 1

HCID 221388532-Isopropoxypyrimidine

Conditions

Temperature
130 °C

Procedure

A 2-chloropyrimidine was dissolved in isopropyl alcohol to which was added diisopropylamine. The reaction was heated in a sealed tube for ten days at 130° C. The cooled reaction mixture was concentrated, and the product purified via silica gel column chromatography to yield the 2-isopropoxypyrimidine.

Workup

  1. customThe cooled reaction mixture
  2. concentrationwas concentrated
  3. customthe product purified via silica gel column chromatography

Sources & evidence

ORD record
ord-5eeae7a57a0340a0ac9a97edec8fd5c5
Source dataset
uspto-grants-2010_06
Patent number
US07741328B2

Linked notes

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