1-Butanol → 5-Iodo-3-(trifluoromethyl)pyridin-2-amine

Reaction equation

[Br:1][c:2]1[cH:3][c:4]([C:9]([F:10])([F:11])[F:12])[c:5]([NH2:8])[n:6][cH:7]1.[CH2:21]([OH:22])[CH2:23][CH2:24][CH3:25].[CH3:15][NH:16][CH2:17][CH2:18][NH:19][CH3:20].[Cu:26][I:27].[I-:14].[Na+:13]>>[c:2]1([I:14])[cH:3][c:4]([C:9]([F:10])([F:11])[F:12])[c:5]([NH2:8])[n:6][cH:7]1

Participants

Reactant 6

HCID 2631-Butanol

HCID 923Sodium Ion

HCID 8070N,N'-Dimethylethylenediamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 30165Iodide Ion

HCID 205253835-Bromo-3-(trifluoromethyl)pyridin-2-amine

Product 1

HCID 582353065-Iodo-3-(trifluoromethyl)pyridin-2-amine

Sources & evidence

ORD record: ord-d00b18a7b1d74069b82417061e3f6c15
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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