(E)-4-(4-Fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester → 4-(4-Fluoro-phenyl)-4-methyl-pentanoic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:17])/[CH:5]=[CH:6]/[C:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])[CH3:2]>CO.[Pt](=O)=O>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][CH2:6][C:7]([C:10]1[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=1)([CH3:9])[CH3:8])[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of (E)-4-(4-fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester (4.10 g) in methanol (150 ml) at room temperature was added platinum(IV) oxide (788 mg). The mixture was stirred under an atmosphere of hydrogen (1 atm) at room temperature for 2 h. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to yield a yellow oil, (3.97 g, 96%); MS (ISP): 239.2 ([M+H]+).