Trifluoroacetic acid → HCID 86655088, compound

HRID 1809202

Reaction equation

HRID 1809202 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[C:8]([C:10]1[CH:11]=[C:12]([S:16]([NH2:19])(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1)#[N:9]>CCO.[Pd]>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[NH2:9][CH2:8][C:10]1[CH:11]=[C:12]([S:16]([NH2:19])(=[O:17])=[O:18])[CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 28087183-Cyanobenzene-1-sulfonamide

Product 1

HCID 86655088HCID 86655088, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

TFA (5 mL) can be added to a solution of 3-cyano-benzenesulfonamide (0.90 g, 4.94 mmol) in EtOH (50 mL) followed by Pd/C (100 mg) and the mixture hydrogenated at 40 psi and r.t. for 20 h. The reaction mixture can be filtered through celite and the solvent concentrated to give 3-Aminomethyl-benzenesulfonamide TFA salt as a white solid in quantitative yield.

Workup

  1. filtrationThe reaction mixture can be filtered through celite
  2. concentrationthe solvent concentrated

Sources & evidence

ORD record
ord-e4e9a0a35d394ab39795a9e29dcf9336
Source dataset
uspto-grants-2013_01
Patent number
US08362018B2

Linked notes

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