(Ethoxy-phenyl-phosphinoyl)-hydroxy-acetic acid ethyl ester → Hydroxy-(hydroxy-phenyl-phosphinoyl)-acetic acid
Reaction equation
C([O:3][C:4](=[O:18])[CH:5]([P:7]([O:15]CC)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])[OH:6])C>Cl>[OH:6][CH:5]([P:7]([OH:15])([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8])[C:4]([OH:18])=[O:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of (ethoxy-phenyl-phosphinoyl)-hydroxy-acetic acid ethyl ester (382 mg, 1.41 mmol) in 10 mL of 6 M HCl was heated to reflux overnight. The resulting mixture was concentrated to a minimum volume and lyophilized affording a pale yellow solid (274 mg, 90%)
Workup
- temperatureto reflux overnight
- concentrationThe resulting mixture was concentrated to a minimum volume
Sources & evidence
- ORD record
- ord-add107cf0a0e4bb9af0caf4ab716677b
- Source dataset
- uspto-grants-2005_04
- Patent number
- US06878697B2
Reaction notes
Loading…