Diethylamine → HCID 9816986, compound
Reaction equation
[NH2:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[C:4]([N:6]([CH2:9][CH3:10])[CH2:7][CH3:8])=[O:5].[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16].C12C(=CC=CC=1)[NH:25]C(=O)OC2=O>>[NH:17]1[CH2:18][CH2:19][N:25]=[C:15]1[CH2:16][NH:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[C:4]([N:6]([CH2:7][CH3:8])[CH2:9][CH3:10])=[O:5]Participants
4
Procedure
2-Amino-N,N-diethylbenzamide (prepared from diethylamine and isatoic anhydride, using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give 2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-N,N-diethylbenzamide, isolated as the fumarate salt.
Workup
- customwere reacted