1-Chloro-4-(ethanesulfonyl)-2-nitrobenzene → 1-({[4-(Ethylsulfonyl)-2-nitrophenyl]amino}methyl)cyclopentanol

HRID 1817869

Reaction equation

HRID 1817869 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14].Cl.[NH2:17][CH2:18][C:19]1([OH:24])[CH2:23][CH2:22][CH2:21][CH2:20]1>C(N(CC)CC)C>[CH2:11]([S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:17][CH2:18][C:19]2([OH:24])[CH2:23][CH2:22][CH2:21][CH2:20]2)=[C:3]([N+:13]([O-:15])=[O:14])[CH:4]=1)(=[O:10])=[O:9])[CH3:12]

Participants

4

Reactant 2

HCID 15158591-Chloro-4-(ethanesulfonyl)-2-nitrobenzeneHCID 211096931-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1)

Product 1

HCID 688709041-({[4-(Ethylsulfonyl)-2-nitrophenyl]amino}methyl)cyclopentanol

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 1-chloro-4-(ethylsulfonyl)-2-nitrobenzene (Step C of Example 2), 1-(aminomethyl)cyclopentanol hydrochloride (J. Med. Chem. 1981, 24, 12-16) and triethylamine.

Sources & evidence

ORD record
ord-4d6e73a7a8f24101adf2d6fc9fd8975c
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Linked notes

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