Chloroform → Phenacyl bromide
Reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C(Cl)(Cl)Cl.[Br:14]Br>C(OCC)C.C(Cl)Cl.C(O)(=O)C>[Br:14][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]Participants
7
Reactant 3
Product 1
Reagents, catalysts & solvents 3
Procedure
The appropriate acetophenone (Intermediate A) was dissolved in diethyl ether, methylene chloride, or chloroform, and cooled to 0° C. Bromine (1.1 equiv) was dissolved in either methylenechloride or diethyl ether and added to the solution of acetophenone via a dropping funnel. After the addition of bromine was complete 2 drops of acetic acid were added and the solution was warmed to room temperature. Solvent was removed under reduced pressure to provide crude 2-bromoacetophenone (Intermediate B) which was generally used without further purification.
Workup
- additionwere added
- customSolvent was removed under reduced pressure
Sources & evidence
- ORD record
- ord-0ad0056e4b8948658799532f1f4e42e6
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07741349B2
Reaction notes
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