Perchloric Acid → HCID 59699856, compound
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:9]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:10]OC)[C:5]([NH2:8])=[N:6][CH:7]=1.Cl(O)(=O)(=O)=O>O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]([CH:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A mixture of 5-bromo-3-(1-cyclopentyl-2-methoxy-vinyl)-pyridin-2-ylamine (116.9 mg, 0.39 mmol) and perchloric acid (0.1 mL) in dioxane (1 mL) was heated at 80° C. for 2 hrs. Solvents were evaporated and the residue was washed with a solution of 2M sodium carbonate (5 mL). A precipitate was formed and filtered off. It was washed with water and dried to afford the product 5-bromo-3-cyclopentyl-1H-pyrrolo[2,3-b]pyridine (69.8 mg, 67% yield) as a brown solid. MS: m/z 265/266 [MH+].