hydroxylamine-O-sulfonic acid → 1,3-Benzenedicarbonitrile, 4-fluoro-
Reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][C:3]=1[C:4]#[N:5].[NH2:12]OS(O)(=O)=O>O>[F:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]#[N:12])=[CH:6][C:3]=1[C:4]#[N:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
To a solution of 2-fluoro-5-formylbenzonitrile (5.1 g, 33.9 mmol) in water (75 ml) was added hydroxylamine-O-sulphonic acid (4.6 g, 40.7 mmol) and the reaction mixture was heated at 50° C. for 5 h. The mixture was filtered and the solid material was washed with water and dried in vacuo for 18 h to give the title compound (4.3 g)
Workup
- filtrationThe mixture was filtered
- washthe solid material was washed with water
- customdried in vacuo for 18 h
Sources & evidence
- ORD record
- ord-cef91c3e4cb54f378394874c12c3c473
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07608604B2
Reaction notes
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