Hydrochloric Acid → 2,5-Dimethyl-4-(2-morpholin-4-yl-ethoxy)aniline dihydrochloride

HRID 1822900

Reaction equation

HRID 1822900 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:5]([CH3:17])=[CH:4][C:3]=1[NH:18]C(=O)C.[ClH:22]>>[ClH:22].[ClH:22].[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:5]([CH3:17])=[CH:4][C:3]=1[NH2:18]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22169683N-{2,5-Dimethyl-4-[2-(morpholin-4-yl)ethoxy]phenyl}acetamide

Product 1

HCID 221696742,5-Dimethyl-4-(2-morpholin-4-yl-ethoxy)aniline dihydrochloride

Procedure

The mixture of N-[2,5-dimethyl-4-(2-morpholin-4-yl-ethoxy)-phenyl]-acetamide (11.4 g, 39 mmol) in 3N aq.HCl (100 mL) was refluxed for 2 h and then concentrated under reduced pressure. The residue was lyophilized to give 2,5-dimethyl-4-(2-morpholin-4-yl-ethoxy)aniline dihydrochloride as gray solid quantitatively.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-81c71f63cc804866bd3cc3fc12965995
Source dataset
uspto-grants-2006_05
Patent number
US07037909B2

Linked notes

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