Reaction equation
[S:1]([C:21]1[CH:26]=C(C2C(Cl)=CC(C(F)(F)F)=CC=2Cl)C=C[C:22]=1C)[C:2]1[CH:7]=[C:6]([C:8]2[C:13]([Cl:14])=[CH:12][C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=2[Cl:19])[CH:5]=[CH:4][C:3]=1[CH3:20].C(S([O-])=O)O.[Na+].C(I)(C)C.O>CN(C)C=O>[Cl:19][C:9]1[CH:10]=[C:11]([C:15]([F:17])([F:18])[F:16])[CH:12]=[C:13]([Cl:14])[C:8]=1[C:6]1[CH:5]=[CH:4][C:3]([CH3:20])=[C:2]([S:1][CH:21]([CH3:22])[CH3:26])[CH:7]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
3.3 g (4.9 mmol) of 1,1′-thiodi-[5-(2,6-dichloro-4-trifluoromethylphenyl)-2-methylbenzene], 3,0 g (19.5 mmol) of Rongalite and 3.0 g (17.6 mmol) of isopropyl iodide were stirred in 30 ml of N,N-dimethylformamide at room temperature for 3 hours. The resulting reaction mixture was poured into 300 ml of water and extracted with 50 ml of ethyl acetate twice. The ethyl acetate layer was washed with 50 ml of water twice and dried over anhydrous magnesium sulfate, and the ethyl acetate was distilled off under reduced pressure. Purification of the residue by silica gel column chromatography afforded 1.4 g of [5-(2,6-dichloro-4-trifluoromethylphenyl)-2-methylphenyl]isopropyl sulfide (yield 38.0%) as a yellow dough (nD20 1.5462).
Workup
- customThe resulting reaction mixture
- extractionextracted with 50 ml of ethyl acetate twice
- washThe ethyl acetate layer was washed with 50 ml of water twice
- dry with materialdried over anhydrous magnesium sulfate
- distillationthe ethyl acetate was distilled off under reduced pressure
- customPurification of the residue by silica gel column chromatography
Sources & evidence
- ORD record
- ord-d5c22e8c887b4258ad617601832819bb
- Source dataset
- uspto-grants-2006_05
- Patent number
- US07037930B2
Linked notes
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