1,2-Diamino-4,5-difluorobenzene → HCID 22139821, compound
Reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH2:10].[Cl:11][C:12]1[C:13]([N:17]=[C:18]=[S:19])=[CH:14][S:15][CH:16]=1>C1COCC1>[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH:10][C:18]([NH:17][C:13]1[C:12]([Cl:11])=[CH:16][S:15][CH:14]=1)=[S:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 1,2-diamino-4,5-difluorobenzene (1.02 g) in THF abs. (15 ml) 4-chloro-3-thienylisothiocyanate (1.25 g, example 52c) dissolved in THF abs. (15 ml) was added. Following the analogous description in example 54a) the desired product was obtained (773 mg).
Workup
- addition(15 ml) was added
Sources & evidence
- ORD record
- ord-ac33a32f41d542eb8de4a3416932963c
- Source dataset
- uspto-grants-2006_05
- Patent number
- US07049333B2
Reaction notes
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