Sulfuric Acid → HCID 2953193, compound
Reaction equation
[C:1]([CH:9]([NH:11][C:12](=[O:22])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][CH:20]=O)[CH3:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O>CN1CCCC1=O>[C:2]1([C:1](=[O:8])[CH:9]([N:11]2[C:12](=[O:22])[C:13]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:19]=[CH:20]2)[CH3:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-(1-benzoylethyl)-2-(formylamino)-benzamide in N-methyl-pyrrolidone (“NMP”) is dehydrated with concentrated sulfuric acid, cyclizing to provide 3-(1-phenyl-1-oxoprop-2-yl)-quinazolin-4-one.
Sources & evidence
- ORD record
- ord-ed0ebb716cc24fbcb3d1224ab9c1844f
- Source dataset
- uspto-grants-2006_05
- Patent number
- US07053216B2
Reaction notes
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