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Acetic Anhydride → 1-Cyclohexyl-1-methylethyl propionate

HRID 1829596
Notes
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Reaction equation

HRID 1829596 reaction equation
C[C:2]1(C)[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([OH:11])([CH3:10])[CH3:9])[CH2:3]1.C[Mg]Cl.CC1(C)CCC[CH:19]([C:23](=[O:25])C)[CH2:18]1.C1(C(O)(C)C)CCCCC1.C(OC(=O)C)(=O)C.C(OC(=O)CC)(=O)CC>>[C:23]([O:11][C:8]([CH:4]1[CH2:3][CH2:2][CH2:7][CH2:6][CH2:5]1)([CH3:9])[CH3:10])(=[O:25])[CH2:19][CH3:18]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 6

HCID 7918Acetic AnhydrideHCID 31263Propionic anhydrideHCID 85531Cyclohexanemethanol, alpha,alpha-dimethyl-HCID 913881-(3,3-Dimethylcyclohexyl)ethanoneHCID 22053304HCID 22053304, compoundHCID 178418332HCID 178418332, compound

Product 1

HCID 53950442
1-Cyclohexyl-1-methylethyl propionate

Procedure

The following compounds were prepared analogously to the method described in Example 16, except that the alcohol component used was 2-(3,3-dimethylcyclohexyl)-2-propanol, [which can be prepared from methylmagnesium chloride and 1-(3,3-dimethylcyclohexyl)-ethanone by a Grignard reaction] instead of 2-cyclohexyl-2-propanol. The esterification was carried out with acetic anhydride (Example 18) or propionic anhydride (Example 19). Thus, only the spectroscopic data are indicated at this point:

Workup

  1. customThe following compounds were prepared analogously to the method

Sources & evidence

ORD record
ord-ec0827dca01e40d6ae21a2dce57a9f9e
Source dataset
uspto-grants-2006_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07064102B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes