2-Butanamine, 1-methoxy- → [4-(2,4-Dichloro-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine

HRID 1831513

Reaction equation

HRID 1831513 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[CH:5]=[CH:4][N:3]=1.[CH3:19][O:20][CH2:21][CH:22]([NH2:25])[CH2:23][CH3:24]>>[Cl:18][C:12]1[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=1[C:6]1[CH:5]=[CH:4][N:3]=[C:2]([NH:25][CH:22]([CH2:21][O:20][CH3:19])[CH2:23][CH3:24])[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 938372-Butanamine, 1-methoxy-HCID 220521022-Chloro-4-(2,4-dichloro-phenyl)-3-nitro-pyridine

Product 1

HCID 22052219[4-(2,4-Dichloro-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amineYield 83%

Procedure

2-Chloro-4-(2,4-dichloro-phenyl)-3-nitro-pyridine (0.25 g, 0.82 mmol) and 1-methoxymethyl-propylamine (0.23 g, 1.65 mmol) were treated substantially as described in Part D of Example 9 to produce 0.25 g (83%) of [4-(2,4-dichloro-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine: MS (AP) m/z 370.2 [(M+H)+, 98].

Sources & evidence

ORD record
ord-e106ed2a922949afa1b2d417b551b5ba
Source dataset
uspto-grants-2006_06
Patent number
US07067658B2

Linked notes

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