HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

2-Phenylethanol → Benzeneethanamine, N-ethyl-N-phenyl-

HRID 1833984
Notes
Print preview

Reaction equation

HRID 1833984 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2].[C:10]1([CH2:16][CH2:17]O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.P(OC1C=CC=CC=1)(OC1C=CC=CC=1)OC1C=CC=CC=1>O>[CH2:1]([N:3]([CH2:17][CH2:16][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 60542-PhenylethanolHCID 7540Triphenyl phosphiteHCID 7670N-Ethylaniline

Product 1

HCID 3808329Benzeneethanamine, N-ethyl-N-phenyl-Yield 81%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
243 °C

Procedure

182 parts of N-ethylaniline, 244 parts of phenylethyl alcohol and 20 parts of triphenyl phosphite are mixed whilst stirring and next heated to an internal temperature of 206° C, at which the elimination of water commences. The mixture is then heated to an internal temperature of 243° C in the course of 20 hours. During this time, 25 parts of water have distilled off and the condensation has ended. The excess ethylaniline and the unconverted alcohol are then distilled off. 274 parts of N-ethyl-N-phenylethyl-aniline, corresponding to a yield of 81% of theory, distil at a boiling point of 160° C/5 mm Hg.

Workup

  1. distillationDuring this time, 25 parts of water have distilled off
  2. distillationThe excess ethylaniline and the unconverted alcohol are then distilled off
  3. custom274 parts of N-ethyl-N-phenylethyl-aniline, corresponding to a yield of 81% of theory, distil at a boiling point of 160° C/5 mm Hg

Sources & evidence

ORD record
ord-d10c9fb8df8d4d7db38508085dfec76f
Source dataset
uspto-grants-1978_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04067903

Reaction notes

Loading…

On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes