Hydrochloric Acid → HCID 22677939, compound
Reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:22]>CO>[ClH:22].[ClH:22].[N:19]1[CH:20]=[CH:21][C:16]([NH:15][CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:17][CH:18]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of 1-Boc-4-[(pyrid-4-ylamino)methyl]piperidine (1.0 g, 3.43 mmol) in methanol (100 mL) was added HCl (1 M in ether, 34 mL), and the mixture stirred overnight. The solvent was removed in vacuo, and the resudue taken up in water and freeze dried to give the product as a yellow solid (800 mg, 88%).
Workup
- customThe solvent was removed in vacuo
- customfreeze dried
Sources & evidence
- ORD record
- ord-74db55e3f12147c99ddff08dc9fa6b9a
- Source dataset
- uspto-grants-2004_08
- Patent number
- US06784182B2
Reaction notes
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