Methylamine → Amlodipine

HRID 1837799

Reaction equation

HRID 1837799 reaction equation
[CH3:1][CH2:2][O:3][C:4]([C:6]1[CH:11]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]([C:19]([O:21][CH3:22])=[O:20])=[C:9]([CH3:23])[NH:8][C:7]=1[CH2:24][O:25][CH2:26][CH2:27][N:28]1C(=O)C2C(=CC=CC=2)C1=O)=[O:5].CN>>[CH3:1][CH2:2][O:3][C:4]([C:6]1[CH:11]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]([C:19]([O:21][CH3:22])=[O:20])=[C:9]([CH3:23])[NH:8][C:7]=1[CH2:24][O:25][CH2:26][CH2:27][NH2:28])=[O:5]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 9871958Phthalimidoamlodipine

Product 1

HCID 2162Amlodipine

Conditions

Temperature
0 °C

Procedure

Phthaloyl amlodipine (100 g, 0.18 M) was reacted with monomethyl amine (500 g, 40% solution) in denatured spirit at room temperature for 8 hrs, cooled to 0° C., filtered, washed with distilled water up to neutral pH and dried at 60-65° C. for 8 ills. Yield 58 g.

Workup

  1. filtrationfiltered
  2. washwashed with distilled water up to neutral pH
  3. customdried at 60-65° C. for 8 ills

Sources & evidence

ORD record
ord-0446c85fbae1475e863fd016fb81c07c
Source dataset
uspto-grants-2004_08
Patent number
US06784297B2

Linked notes

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