Hydrochloric Acid → 5,6,7,8-Tetrahydro-1,8-naphthyridin-2-butyric acid hydrochloride
Reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][CH2:12][CH2:13][C:14]([O:16]CC)=[O:15])[N:9]=2)[CH2:4][CH2:3][CH2:2]1.[ClH:19]>>[ClH:19].[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])[N:9]=2)[CH2:4][CH2:3][CH2:2]1Participants
3
Procedure
Ester 2-4 (1.8 g, 7.25 mmol) in 36 mL 6 N HCl was heated at 50° C. for 4 h, then concentrated, providing 2-5 as a yellow solid.
Workup
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-9bcbd9d6c65c439889eb9b922c4c3bc8
- Source dataset
- uspto-grants-2004_08
- Patent number
- US06784190B2
Reaction notes
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