Uracil → Benzyl chloromethyl ether

HRID 1838436

Reaction equation

CN1[C:10]2[C:9](=O)NC(=O)N[C:5]=2N=C1.N1C=[CH:17][C:16](=O)NC1=O.C[Si](C)(C)[CH2:23][CH2:24][O:25][CH2:26][Cl:27]>>[CH2:24]([O:25][CH2:26][Cl:27])[C:23]1[CH:17]=[CH:16][CH:9]=[CH:10][CH:5]=1

Participants

Reactant 3

HCID 1174Uracil

HCID 683747-Methylxanthine

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

Product 1

HCID 137983Benzyl chloromethyl ether

Procedure

In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 7-methylxanthine, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 69%) as a pale yellow powder.

Sources & evidence

ORD record: ord-aabbc1fe7b634686ad862928f82d70f5
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06673804B1

Linked notes

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