Trifluoroacetic acid → 5-(1-methyl-1H-pyrazol-4-yl)pyridine-2-carboxylic acid
Reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[CH:16][C:17]([C:20]([O:22]C(C)(C)C)=[O:21])=[N:18][CH:19]=2)[CH:11]=[N:10]1>ClCCl>[CH3:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[CH:16][C:17]([C:20]([OH:22])=[O:21])=[N:18][CH:19]=2)[CH:11]=[N:10]1Participants
4
Procedure
TFA (1 mL) was added to a solution of tert-butyl 5-(1-methyl-1H-pyrazol-4-yl)-pyridine-2-carboxylate (81 mg) in dichloromethane (4 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to obtain a crude product of the title compound (170 mg).
Workup
- customThe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-07238317d92a482db20c764d8267f0c0
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08946211B2
Reaction notes
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