Hydrazine hydrate (1:1) → 2-(1H-Pyrazol-3-Yl)Pyridine

HRID 1844502

Reaction equation

HRID 1844502 reaction equation
C[N:2](C)/[CH:3]=[CH:4]\[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=O.O.[NH2:15]N>C(O)C>[NH:2]1[CH:3]=[CH:4][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[N:15]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86719369(Z)-3-(dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one

Product 1

HCID 27976572-(1H-Pyrazol-3-Yl)PyridineYield 97.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 16a (1 g, 6.2 mmol) obtained from the aforesaid process and hydrazine hydrate (2 mL) were dissolved in ethanol (3.3 mL), and reacted at 60° C. for 0.5 hour. Then, the mixture was cooled to room temperature, and then the solvent was removed in vacuum to afford the product 17a (874.7 mg) as a faint yellow solid, with a yield of 97.3%.

Workup

  1. customreacted at 60° C. for 0.5 hour
  2. customthe solvent was removed in vacuum

Sources & evidence

ORD record
ord-8efd030e96c24c988ac782956cba7793
Source dataset
uspto-grants-2015_02
Patent number
US08946436B2

Linked notes

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