Di-tert-butyl dicarbonate → HCID 89964768, compound
Reaction equation
Br[C:2]1[C:7]([N:8]([CH2:16][CH2:17][CH:18]=C)[C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=[CH:4][N:3]=1.BrC1C(NCCC=C)=CC=CN=1.CC([O:36]C(OC(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[O:36]=[C:18]1[C:2]2[C:7](=[CH:6][CH:5]=[CH:4][N:3]=2)[N:8]([C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[CH2:16][CH2:17]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
tert-butyl (2-bromopyridin-3-yl)(but-3-en-1-yl)carbamate. To a solution of 2-bromo-N-(but-3-en-1-yl)pyridin-3-amine (1 eq.) and DCM (0.2 M) is added (Boc)2O (1.5 eq.). The solution is stirred at room temperature until judged complete by TLC. The solution is concentrated in vacuo and purified by column chromatography to give the title compound.