Dichloromethane → HCID 89964896, compound

Reaction equation

[NH:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3][CH2:2]1.C(Cl)Cl.CCN(C(C)C)C(C)C.[C:24](Cl)(=[O:26])[CH3:25]>>[C:24]([N:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3][CH2:2]1)(=[O:26])[CH3:25]

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 6367Acetyl chloride

HCID 81531Diisopropylethylamine

HCID 54710388HCID 54710388, compound

Product 1

HCID 89964896HCID 89964896, compound

Procedure

To a solution of 2,3-dihydro-1,5-naphthyridin-4(1H)-one (1 eq.) and DCM (0.2 eq.) is added DIEA (2.2 eq.) and acetyl chloride (1.2 eq.). The reaction is monitored by TLC. The reaction is washed with water, brine, dried over MgSO4, concentrated in vacuo, and purified by column chromatography to give the title compound.