Methoxyacetic Acid → 2-(methoxymethyl)-4-methyl-1H-benzo[d]imidazol-6-ol

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([OH:10])[CH:5]=[C:6]([CH3:9])[C:7]=1[NH2:8].[CH3:11][O:12][CH2:13][C:14](O)=O>>[CH3:11][O:12][CH2:13][C:14]1[NH:1][C:2]2[CH:3]=[C:4]([OH:10])[CH:5]=[C:6]([CH3:9])[C:7]=2[N:8]=1

Participants

Reactant 2

HCID 12251Methoxyacetic Acid

HCID 199076443,4-Diamino-5-methylphenol

Product 1

HCID 669782392-(methoxymethyl)-4-methyl-1H-benzo[d]imidazol-6-ol

Procedure

0.55 g (4.00 mmol) 3,4-diamino-5-methyl-phenol and 1.57 mL (20.00 mmol) methoxy-acetic acid were stirred for 1 h at 120° C. Then the reaction mixture was evaporated down and further reacted as crude product.

Workup

customThen the reaction mixture was evaporated down
customfurther reacted as crude product

Sources & evidence

ORD record: ord-0a9782ae3d6c474b9a96289133f1de66
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08952014B2

Reaction notes

Loading…