Trifluoroacetic acid → Trifluoroacetic acid

HRID 1846741

Reaction equation

HRID 1846741 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([NH:7]C(=O)OC(C)(C)C)[S:5][CH:6]=1.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:7])[S:5][CH:6]=1.[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 574719832-(Boc-amino)-4-methylthiophene

Product 2

HCID 6422Trifluoroacetic acidHCID 122311924-Methylthiophen-2-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 4-methylthiophen-2-ylcarbamate (0.880 g, 4.13 mmol) in CH2Cl2 (8 mL) and TFA (6 mL) wad stirred at room temperature for 3 h. Solvents was removed in vacuo to give 4-methylthiophen-2-amine as trifluoroacetic acid salt (0.920 g).

Workup

  1. customSolvents was removed in vacuo

Sources & evidence

ORD record
ord-5af6f8ec47ba49238569a926d5c0d60f
Source dataset
uspto-grants-2015_02
Patent number
US08952027B2

Linked notes

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