Sodium Hydroxide → HCID 68295126, compound
Reaction equation
[OH-].[Na+].[CH3:3][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]2[CH:15]=[C:14](/[CH:16]=[CH:17]/[C:18]([O:20]C)=[O:19])[CH:13]=[N:12]2)[CH2:6][CH2:5]1>CO.C1COCC1>[CH3:3][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]2[CH:15]=[C:14](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])[CH:13]=[N:12]2)[CH2:6][CH2:5]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
An aqueous 3N sodium hydroxide solution (2 mL) was added to a solution of (E)-methyl 3-(1-((1-methylpiperidin-4-yl)methyl)-1H-pyrazol-4-yl)acrylate (220 mg) in MeOH (5 mL) and THF (3 mL) was added aq NaOH (3N, 2 mL) to saponify the methyl ester. Workup was performed as described in Example 12 to generate 209 mg of pure product (0.84 mmol, 100%).